Custom Peptides
Cayman Chemical LIthospermosIde 10mg
A nitrile glucoside with antitumor activity; inhibits TPA-induced activation of EBV-EA in Raji cells
Cayman Chemical RhamnopterIn 10mg
A derivative of biopterin; reduces the incidence of 4-dimethylaminoazobenzene-induced liver tumors in rats at 0.5% in the diet concurrently with 4-dimethylaminoazobenzene; has been used as an internal standard for the quantification of biopterin and neopterin in rat plasma by LC-MS
Cayman Chemical TreprostInIldIethnolamIn 10mg
An agonist of IP2, DP2, and EP2 receptors; binds selectively to IP2, DP2, and EP2 over EP1, EP3, and EP4 receptors (Kis = 32, 4.4, 3.6, 212, 2,505, and 826 nM, respectively, in radioligand binding assays); inhibits LPS-induced production of TNF-α, IL-1β, IL-6, and GM-CSF in in isolated human alveolar macrophages at 200 ng/ml; relaxes isolated small pulmonary arteries and veins precontracted with U-46619; reduces right ventricular systolic pressure compared to hypoxic and sham control animals in a mouse model of chronic hypoxic pulmonary hypertension
Cayman Chemical 12-ProstaglndIn D2 10mg
PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. .DELTA.12-PGD2 is one of the initial chemical decomposition products of PGD2. .DELTA.12-PGD2 is an intermediate in the pathway leading to .DELTA.12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of .DELTA.12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Cayman Chemical StIrIpentol 10mg
An antiepileptic compound; positive allosteric modulator of GABAA receptors that potentiates GABA-mediated activation of α3 subunit-containing GABAA receptors; inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices; inhibits LDH1 and LDH4 at 500 µM
Cayman Chemical mthyl AracHDnyl Fluoropho 10mg
An inhibitor of MAGL and FAAH (IC50s = 26.3 and 0.33 nM, respectively); irreversible inhibitor of cPLA2, as well as iPLA2 (IC50 = 500 nM); inhibits A23187-induced arachidonic acid release from human platelets (IC50 = 600 nM)
Cayman Chemical Fenclofenac 10mg
An NSAID and COX inhibitor (IC50s = 7 and 4 µM for COX-1 and COX-2, respectively); reduces paw volume in a rat model of adjuvant-induced polyarthritis at 3, 15, and 75 mg/kg; induces antinociception in rats (ED50 = 54.3 mg/kg); reduces carrageenan-induced paw edema in rats at 20-180 mg/kg
Cayman Chemical SURVODUTIDE 10MG
A dual peptide agonist of GLP-1R and GCGR; increases cAMP accumulation in CHO-K1 cells expressing GLP-1R or GCGR in reporter assays (EC50s = 0.33 and 0.52 nM, respectively); potentiates glucose-induced insulin secretion in isolated mouse, rat, and perifused human pancreatic islets; reduces body weight and food intake in diet-induced obese mice at 3 and 30 nmol/kg per day; reduces the levels of hepatic triglycerides and cholesterol, as well as plasma levels of glucagon, cholesterol, triglycerides, ALT, AST, insulin, and leptin in diet-induced obese mice; increases energy expenditure in diet-induced obese mice at 10 nmol/kg per day
Cayman Chemical ProtrIptylInhydrochlorIde 10mg
A tricyclic antidepressant; binds to the norepinephrine and 5-HT transporters (Kd = 1.41 and 19.6 nM, respectively); binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively); inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM); inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg, i.v.
Cayman Chemical ResorcInolnaphthaleIn 10mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)
Cayman Chemical NItazoxnIde 10mg
A prodrug form of tizoxanide; inhibits C. parvum growth in MDBK cells at 10 UG/ml; active against M. tuberculosis and M. bovis (MIC = 16 UG/ml for both); inhibits SARS-CoV-2 and MERS-CoV replication at 5 and 10 µM; inhibits replication of H1N1 PR8 and WSN, as well as H5N9 A/Ck viruses (EC50s = 1, 0.5, and 1 UG/ml, respectively); reduces oocyst shedding and parasite burden, but not the severity of diarrhea, in a gnotobiotic piglet model of C. parvum infection at 250 mg/kg
Cayman Chemical GInsenosIde Rb2 10mg
A natural steroid glycoside with diverse effects; inhibits LPS-stimulated increases in VCAM-1 and ICAM-1 expression; reverses LPS-stimulated decreases in the expression of IκBα in HUVECs in a dose-dependent manner; reduces UVB-induced cytotoxicity and apoptotic nuclear fragmentation in HaCaT cells; lowers total cholesterol and triacylglycerol in 3T3-L1 adipocytes cultured under high fatty acid conditions to levels comparable to lovastatin
Cayman Chemical 1ArachIdoyl2Oleoyl3PalmI 10mg
A triacylglycerol; has been found in a variety of plant oils, including poppy seed, hazelnut, maize, olive, yellow melon, and date seed oils
