Custom Peptides
Cayman Chemical JWH 018 N 1 2dImthylPRYl 10mg
Differs from JWH 018 structurally by having a 1,2-dimethylpropyl chain, rather than a pentyl chain, extending from the indole group; intended for forensic purposes
Cayman Chemical EB 47hydrochlorIde 10mg
A PARP1 and TNKS2 inhibitor (IC50 = 45 nM for both); an inhibitor of TNKS1 and PARP10 (IC50s = 410 and 1,179 nM, respectively); reduces infarct volume in a rat model of MCAO occlusion-induced ischemia-reperfusion injury at 10 mg/kg per hour
Cayman Chemical 5 8 11EIcosatrIynoIc AcId 10mg
5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM.{66} 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM.{650} At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases (ID50 = 340 µM).{66}
Cayman Chemical ImeglImInhydrochlorIde 10mg
An anti-hyperglycemic compound; inhibits high-glucose- or tert-butyl hydroperoxide-induced cell death in HMEC-1 cells at 100 µM; reduces tert-butyl hydroperoxide-induced cytochrome c levels, as well as mitochondrial membrane permeability without affecting mitochondrial respiration, in HMEC-1 cells at 100 µM; decreases plasma glucose levels and increases plasma insulin levels in a rat model of high-fat diet-induced obesity at 150 mg/kg in the diet; reduces colonic balloon-induced pain-related muscle contractions in rats at 100 mg/kg; reduces colonic hyperpermeability in a rat model of LPS-induced IBS at 100 mg/kg
Cayman Chemical Paubrasla echnta Brazlen 10mg
A phytochemical with diverse biological activities; active against E. coli, P. aeruginosa, and MSSA (MICs = 32, 512, and 512 UG/ml), as well as a panel of 10 clinical isolates of MRSA (MIC50s = 16-32 UG/ml); inhibits LPS-induced NO production in J774A.1 cells at 10 µM; cytotoxic to HepG2, Hep3B, MDA-MB-231, MCF-7, A549, and Ca9-22 cancer cells (IC50s = 3.15, 3.42, 2.36, 3.96, 9.68, and 8.63 UG/ml, respectively); inhibits concanavalin A-induced proliferation of isolated mouse spleen lymphocytes from 1-10 UG/ml
Cayman Chemical 3 6-DIsInapoylsucrose 10mg
An oligosaccharide ester with antidepressant- and anxiolytic-like activities; prevents increases in serum cortisol levels, serum SOD activity, and brain MAO-A and MAO-B levels, as well as decreases serum MDA levels, in a rat model of chronic mild stress; increases sucrose consumption in the sucrose preference test, indicating antidepressant-like activity, in the same model at 20 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, from 3 to 12 mg/kg
Cayman Chemical Rlpvrn 10mg
A non-nucleoside reverse transcriptase inhibitor; inhibits growth of wild-type (EC50 = 0.51 nM) and NNRTI-resistant HIV strains (EC50s = <1 nM for L100I, K103N, V106A, G190A, and G190S mutants); reduces the plasma viral titer in HIV-1 infected humanized mice when used in combination with cabotegravir, lamivudine, and abcavir
Cayman Chemical MelItracenhydrochlorIde 10mg
A thymoleptic and tricyclic antidepressant; inhibits 5-HT uptake in rat brain synaptosomes (IC50 = 670 nM); increases the lethality of yohimbine in mice at 20 and 40 mg/kg
Cayman Chemical BenzamIlhydrochlorIde 10mg
An ENaC blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles; an NCX blocker that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 ~ 100 nM); an inhibitor of TRPP3 (IC50 = 1.1 μM)
Cayman Chemical 2MethoxymethcathInonhydro 10mg
A positional isomer of methedrone, having the methoxy group at the 2 rather than the 4 position; intended for forensic and research applications
Cayman Chemical ComplnatusIde 10mg
A flavonoid glucoside; inhibits NO production in LPS-stimulated RAW 264.7 cells (IC50 = 21.2 μM)
Cayman Chemical Eurycomnon 10mg
A quassinoid; active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 UG/ml, respectively); induces lipolysis in 3T3-L1 adipocytes (EC50 = 14.6 µM); induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells at 5 UG/ml; reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations at 1 and 10 µM; decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation at 1 mg/kg
Cayman Chemical Dehydro NIfedIpIn 10mg
An active metabolite of nifedipine; formed when nifedipine is metabolized by CYP3A4 and CYP3A5; inhibits glucose uptake in PC-12 cells (IC50 = 130 μM)
Cayman Chemical Pcralma ntda Akuamn 10mg
An indole alkaloid with analgesic activity; selectively binds the μ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively); inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively); increases the latency to withdrawal in the tail-flick or hot plate test in mice at 60 mg/kg
Cayman Chemical TASP0277308 10mg
An S1P1 antagonist (IC50 = 4.2 nM); selective for S1P1 over S1P3, S1P4, and S1P5 (IC50s = >10,000, >10,000, and 8,756 nM, respectively); inhibits S1P-induced [35S]GTPγS binding and forskolin-induced cAMP production in HEK293 cells expressing human S1P1 (IC50s = 7.8 and 4.3 nM, respectively); inhibits S1P-induced migration of CHO cells expressing human S1P1 (IC50 = 18 nM); induces lymphopenia in mice at 100 mg/kg; reduces bone erosion in a mouse model of collagen-induced arthritis; intrathecal administration reduces flinching and guarding behaviors in a mouse model of cancer-induced bone pain at 3 or 10 nmol/animal